She is the author of Closing the Innovation Gap, published in September, 2008. Prior to co-founding Packet Design, in May 2000, Estrin was chief technology officer for Cisco Systems. Beginning in 1981 Estrin co-founded three other successful technology companies: Bridge Communications, Network Computing Devices, and Precept Software. In 1998 Cisco Systems acquired Precept, and she became Cisco's chief technology officer until April 2000.
Estrin has been named three times to Fortune Magazine's list of the 50 most powerful women in American business. She sits on the boards of directors of The Walt Disney Company and FedEx Corporation as well as the privately held Packet Design, Inc. She also sits on the advisory councils of Stanford's School of Engineering and Stanford's Bio-X initiative. She holds a B.S. degree in math and computer science from UCLA, and an M.S. in electrical engineering from Stanford University.